Jin Chu Selected Research

Arachidonate 5-Lipoxygenase (5 Lipoxygenase)

1/2016	The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.
11/2015	Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.
5/2014	Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.
9/2013	The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence.
9/2013	5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease.
9/2012	5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.
6/2012	Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.
4/2011	Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
1/2011	5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.

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Jin Chu Research Topics

Disease

26	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 11/2010
7	Cognitive Dysfunction 10/2019 - 09/2006
6	Amyloidosis 01/2016 - 11/2010
5	Memory Disorders (Memory Loss) 01/2016 - 01/2012
3	Neuroinflammatory Diseases 01/2016 - 05/2014
2	Liver Cirrhosis (Hepatic Cirrhosis) 06/2022 - 01/2022
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 01/2009
2	Inflammation (Inflammations) 01/2016 - 09/2013
2	Tauopathies 11/2015 - 12/2013
2	Dementia (Dementias) 01/2008 - 09/2006
1	Alveolar echinococcosis 03/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Intracranial Aneurysm (Cerebral Aneurysm) 01/2020
1	Aneurysm (Aneurysms) 01/2020
1	Reperfusion Injury 10/2019
1	Wounds and Injuries (Trauma) 11/2018
1	Pain (Aches) 05/2018
1	Down Syndrome (Down's Syndrome) 01/2016
1	Synucleinopathies 08/2015
1	Gliosis 05/2014
1	Amyloid Plaque 01/2014
1	Atrophy 09/2006

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 01/2016 - 01/2008
10	Amyloid (Amyloid Fibrils)IBA 05/2015 - 04/2011
9	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2016 - 01/2011
7	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2016 - 11/2010
5	Amyloid beta-PeptidesIBA 01/2016 - 01/2012
4	EnzymesIBA 01/2016 - 01/2012
3	Caspase 3 (Caspase-3)IBA 10/2019 - 04/2015
3	Peptides (Polypeptides)IBA 01/2016 - 11/2010
3	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 12/2013 - 11/2010
2	icariinIBA 08/2015 - 01/2014
2	tau Proteins (tau Protein)IBA 09/2013 - 01/2012
2	Hormones (Hormone)IBA 08/2013 - 01/2012
2	GlucocorticoidsIBA 08/2013 - 01/2012
1	Amino Acids FDA Link 06/2022
1	Nucleic AcidsIBA 06/2022
1	Becaplermin (PDGF-BB)FDA Link 03/2022
1	Biomarkers (Surrogate Marker)IBA 03/2022
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2022
1	Atorvastatin (Lipitor)FDA Link 01/2020
1	EmulsionsIBA 01/2020
1	lactide-caprolactone copolymerIBA 01/2020
1	esculetinIBA 10/2019
1	Beclin-1IBA 10/2019
1	SolutionsIBA 05/2018
1	CaspasesIBA 05/2015
1	CyclinsIBA 02/2015
1	IsoprostanesIBA 02/2015
1	Phosphotransferases (Kinase)IBA 02/2015
1	HomocysteineIBA 06/2014
1	EpitopesIBA 05/2014
1	LipopolysaccharidesIBA 05/2014
1	Cyclin-Dependent Kinase 5IBA 05/2014
1	SilverIBA 01/2014
1	Congo RedIBA 01/2014
1	LipidsIBA 12/2013
1	zileuton (Zyflo)FDA Link 01/2013
1	Staphylococcal Protein A (Protein A)IBA 01/2012
1	Messenger RNA (mRNA)IBA 01/2012
1	Biological ProductsIBA 01/2009
1	FlavonoidsIBA 01/2008
1	Nerve Growth Factors (Neurotrophins)IBA 09/2006

Therapy/Procedure

1	Transplantation 01/2022
1	Stents 01/2020
1	Operative Surgical Procedures 11/2018
1	Music Therapy 05/2018
1	Therapeutics 01/2016